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KMID : 1161520190230050365
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Animal Cells and Systems
2019 Volume.23 No. 5 p.365 ~ p.369
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Prognostic role of the beta-2 adrenergic receptor in clear cell renal cell carcinoma
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Ha Mi-Hyang
Kim Dong-Woo
Kim Ja-Young
Hong Chae-Mi
Park Su-Min
Woo In-Ae
Kim Min-Yong
Koo Hyun-Jun
Namkoong Jin
Kim Jae-Hyun
Han Myoung-Eun
Song Park-Yong
Hur Jin
Kang Chi-Dug
Kim Yun-Hak
Lee Dong-Jun
Oh Sae-Ock
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Abstract
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The beta-2 adrenergic receptor (ADRB2) regulates the proliferation, apoptosis, angiogenesis, migration, and metastasis of cancer cells. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that ADRB2 can be a novel prognostic factor for patients with ccRCC. The differential expression of ADRB2 in low-stage (stages I and II), high-stage (stages III and IV), low-grade (grades I and II), and high-grade (grades III and IV) ccRCC was identified in cohorts of patients from The Cancer Genome Atlas and the International Cancer Genome Consortium. We evaluated ADRB2 expression as a prognostic factor using the Kaplan-Meier survival curve, multivariate analysis, time-dependent area under the curve (AUC) of Uno’s C-index, and AUC of the receiver operating characteristics (ROC) at five years. Kaplan-Meier analysis revealed that reduced ADRB2 expression is associated with poor prognosis in ccRCC patients. Analysis of C-indices and AUC-ROC further confirmed this result. Moreover, multivariate analysis confirmed the prognostic significance of ADRB2 expression. Collectively, these findings suggest that ADRB2 is a potential prognostic factor for ccRCC.
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KEYWORD
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ADRB2, ICGC, TCGA, ccRCC
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